https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The role of cocaine- and amphetamine- regulated transcript (CART) and orexin in drug- seeking and addiction-related behaviours https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14038 Wed 11 Apr 2018 14:55:16 AEST ]]> Insights for developing pharamacological treatments for psychostimulant replapse targeting hypothalamic peptide systems https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14897 R1) signaling within the ventral tegmental area (VTA) alters Fos-protein expression in relapse-relevant regions, including the PVT and the nucleus accumbens shell (NacS). Further, whilst previous findings have shown that blockade of OXR1 in the VTA prevents reinstatement of Cocaine seeking, we show here that this treatment does not affect natural reward seeking for sweetened condensed milk. In light of the reviewed body of literature, as well as the novel data presented, we discuss the considerations for future pharmacotherapies targeting the orexin and CART systems for relapse prevention.]]> Wed 11 Apr 2018 14:47:04 AEST ]]> Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27445 Wed 11 Apr 2018 12:10:23 AEST ]]> Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14350 +). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S+-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.]]> Wed 11 Apr 2018 11:48:59 AEST ]]> Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14891 Wed 11 Apr 2018 11:35:05 AEST ]]> Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14894 Wed 11 Apr 2018 10:51:50 AEST ]]> Drug-induced changes to lateral hypothalamic circuits and downstream projection targets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21950 Wed 11 Apr 2018 09:46:58 AEST ]]> Characterizing changes in the orexin system in models of neuropsychiatric disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27474 Thu 13 Sep 2018 16:54:06 AEST ]]>